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Cysteine-based protein folding modulators for trapping intermediates and misfolded forms

Folding is a key process to form functional conformations of proteins. Folding via on-pathway intermediates leads to the formation of native structures, while folding through off-pathways affords non-native and disease-causing forms. Trapping folding intermediates and misfolded forms is important fo...

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Detalles Bibliográficos
Autores principales: Nishino, Hayato, Kitamura, Mai, Okada, Shunsuke, Miyake, Ryosuke, Okumura, Masaki, Muraoka, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490518/
https://www.ncbi.nlm.nih.gov/pubmed/36275147
http://dx.doi.org/10.1039/d2ra04044a