Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice

Hepatic steatosis associated with high-fat diet, obesity, and type 2 diabetes is thought to be the major driver of severe liver inflammation, fibrosis, and cirrhosis. Cytosolic acetyl CoA (AcCoA), a central metabolite and substrate for de novo lipogenesis (DNL), is produced from citrate by ATP-citra...

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Detalles Bibliográficos
Autores principales: Yenilmez, Batuhan, Kelly, Mark, Zhang, Guo-Fang, Wetoska, Nicole, Ilkayeva, Olga R., Min, Kyounghee, Rowland, Leslie, DiMarzio, Chloe, He, Wentao, Raymond, Naideline, Lifshitz, Lawrence, Pan, Meixia, Han, Xianlin, Xie, Jun, Friedline, Randall H., Kim, Jason K., Gao, Guangping, Herman, Mark A., Newgard, Christopher B., Czech, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490592/
https://www.ncbi.nlm.nih.gov/pubmed/35988648
http://dx.doi.org/10.1016/j.jbc.2022.102401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490592/
https://www.ncbi.nlm.nih.gov/pubmed/35988648
http://dx.doi.org/10.1016/j.jbc.2022.102401

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