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Resolving molecular diffusion and aggregation of antibody proteins with megahertz X-ray free-electron laser pulses

X-ray free-electron lasers (XFELs) with megahertz repetition rate can provide novel insights into structural dynamics of biological macromolecule solutions. However, very high dose rates can lead to beam-induced dynamics and structural changes due to radiation damage. Here, we probe the dynamics of...

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Detalles Bibliográficos
Autores principales: Reiser, Mario, Girelli, Anita, Ragulskaya, Anastasia, Das, Sudipta, Berkowicz, Sharon, Bin, Maddalena, Ladd-Parada, Marjorie, Filianina, Mariia, Poggemann, Hanna-Friederike, Begam, Nafisa, Akhundzadeh, Mohammad Sayed, Timmermann, Sonja, Randolph, Lisa, Chushkin, Yuriy, Seydel, Tilo, Boesenberg, Ulrike, Hallmann, Jörg, Möller, Johannes, Rodriguez-Fernandez, Angel, Rosca, Robert, Schaffer, Robert, Scholz, Markus, Shayduk, Roman, Zozulya, Alexey, Madsen, Anders, Schreiber, Frank, Zhang, Fajun, Perakis, Fivos, Gutt, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490738/
https://www.ncbi.nlm.nih.gov/pubmed/36130930
http://dx.doi.org/10.1038/s41467-022-33154-7