Scalable synthesis and structural characterization of reversible KLK6 inhibitors

Scalable asymmetric syntheses of two kallikrein-related protease 6 (KLK6) inhibitors are reported. The inhibitors are assembled by linking enantiomerically enriched fragments via amide bond formation, followed by conversion of a cyano group to an amidine. One fragment, an amine, was prepared using t...

Descripción completa

Detalles Bibliográficos
Autores principales: Baumann, Andreas, Isak, Daniel, Lohbeck, Jasmin, Jagtap, Pravin Kumar Ankush, Hennig, Janosch, Miller, Aubry K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490775/
https://www.ncbi.nlm.nih.gov/pubmed/36320846
http://dx.doi.org/10.1039/d2ra04670a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490775/
https://www.ncbi.nlm.nih.gov/pubmed/36320846
http://dx.doi.org/10.1039/d2ra04670a

Ejemplares similares