Kinetic Resolution of 2-Aryl-4-methylenepiperidines toward Enantioenriched Functionalizable Piperidine Fragments

[Image: see text] The base n-BuLi with sparteine allows a kinetic resolution of N-Boc-2-aryl-4-methylenepiperidines. The 2,2-disubstituted products and recovered starting materials were isolated with high enantiomeric ratios. From VT-NMR spectroscopy and DFT studies, the rate of rotation of the N-Bo...

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Detalles Bibliográficos
Autores principales: Choi, Anthony, Meijer, Anthony J. H. M., Silvestri, Ilaria Proietti, Coldham, Iain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490820/
https://www.ncbi.nlm.nih.gov/pubmed/35699313
http://dx.doi.org/10.1021/acs.joc.2c00862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490820/
https://www.ncbi.nlm.nih.gov/pubmed/35699313
http://dx.doi.org/10.1021/acs.joc.2c00862

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