Asymmetric Cascade Aza-Henry/Lactamization Reaction in the Highly Enantioselective Organocatalytic Synthesis of 3-(Nitromethyl)isoindolin-1-ones from α-Amido Sulfones

[Image: see text] The asymmetric synthesis of novel 3-substituted isoindolinones is herein reported. A new cascade reaction was developed that consisted of the asymmetric nitro-Mannich reaction of suitable α-amido sulfones designed from 2-formyl benzoates, followed by the in situ cyclization of the...

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Detalles Bibliográficos
Autores principales: Serusi, Lorenzo, Palombi, Laura, Pierri, Giovanni, Mola, Antonia Di, Massa, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490826/
https://www.ncbi.nlm.nih.gov/pubmed/35699594
http://dx.doi.org/10.1021/acs.joc.2c00518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490826/
https://www.ncbi.nlm.nih.gov/pubmed/35699594
http://dx.doi.org/10.1021/acs.joc.2c00518

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