Synthesis of β(2,2)-Amino Acids by Stereoselective Alkylation of Isoserine Derivatives Followed by Nucleophilic Ring Opening of Quaternary Sulfamidates

[Image: see text] Chiral bicyclic N,O-acetal isoserine derivatives have been synthesized by an acid-catalyzed tandem N,O-acetalization/intramolecular transcarbamoylation reaction between conveniently protected l-isoserine and 2,2,3,3-tetramethoxybutane. The delicate balance of the steric interaction...

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Detalles Bibliográficos
Autores principales: Tovillas, Pablo, Navo, Claudio D., Oroz, Paula, Avenoza, Alberto, Corzana, Francisco, Zurbano, María M., Jiménez-Osés, Gonzalo, Busto, Jesús H., Peregrina, Jesús M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490828/
https://www.ncbi.nlm.nih.gov/pubmed/35732024
http://dx.doi.org/10.1021/acs.joc.2c01034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490828/
https://www.ncbi.nlm.nih.gov/pubmed/35732024
http://dx.doi.org/10.1021/acs.joc.2c01034

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