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Platform for Orthogonal N-Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents

[Image: see text] Protein conjugates are valuable tools for studying biological processes or producing therapeutics, such as antibody–drug conjugates. Despite the development of several protein conjugation strategies in recent years, the ability to modify one specific amino acid residue on a protein...

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Detalles Bibliográficos
Autores principales: Istrate, Alena, Geeson, Michael B., Navo, Claudio D., Sousa, Barbara B., Marques, Marta C., Taylor, Ross J., Journeaux, Toby, Oehler, Sebastian R., Mortensen, Michael R., Deery, Michael J., Bond, Andrew D., Corzana, Francisco, Jiménez-Osés, Gonzalo, Bernardes, Gonçalo J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9490850/
https://www.ncbi.nlm.nih.gov/pubmed/35658467
http://dx.doi.org/10.1021/jacs.2c02185