Enantioselective synthesis of (−)-tetrabenazine via continuous crystallization-induced diastereomer transformation

A multi-well continuous CIDT approach with inline racemization of the solution phase is presented. Using two in-house built PATs and a flow reactor, we were able to successfully crystallize an enantiopure salt of TBZ, the active metabolite of the tardive dyskinesia drug valbenazine. Despite discover...

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Detalles Bibliográficos
Autores principales: Kukor, Andrew J., Depner, Noah, Cai, Isabelle, Tucker, John L., Culhane, Jeffrey C., Hein, Jason E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491067/
https://www.ncbi.nlm.nih.gov/pubmed/36320713
http://dx.doi.org/10.1039/d2sc01825j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491067/
https://www.ncbi.nlm.nih.gov/pubmed/36320713
http://dx.doi.org/10.1039/d2sc01825j

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