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Enantioselective synthesis of (−)-tetrabenazine via continuous crystallization-induced diastereomer transformation
A multi-well continuous CIDT approach with inline racemization of the solution phase is presented. Using two in-house built PATs and a flow reactor, we were able to successfully crystallize an enantiopure salt of TBZ, the active metabolite of the tardive dyskinesia drug valbenazine. Despite discover...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491067/ https://www.ncbi.nlm.nih.gov/pubmed/36320713 http://dx.doi.org/10.1039/d2sc01825j |