Discovery of novel IDH1-R132C inhibitors through structure-based virtual screening

Isocitrate dehydrogenase (IDH) belongs to a family of enzymes involved in glycometabolism. It is found in many living organisms and is one of the most mutated metabolic enzymes. In the current study, we identified novel IDH1-R132C inhibitors using docking-based virtual screening and cellular inhibit...

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Detalles Bibliográficos
Autores principales: Hu, Chujiao, Zeng, Zhirui, Ma, Dan, Yin, Zhixin, Zhao, Shanshan, Chen, Tengxiang, Tang, Lei, Zuo, Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491111/
https://www.ncbi.nlm.nih.gov/pubmed/36160383
http://dx.doi.org/10.3389/fphar.2022.982375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491111/
https://www.ncbi.nlm.nih.gov/pubmed/36160383
http://dx.doi.org/10.3389/fphar.2022.982375

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