FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ

Dysregulation of the Notch–RBPJ (recombination signal-binding protein of immunoglobulin kappa J region) signaling pathway has been found associated with various human diseases including cancers; however, precisely how this key signaling pathway is fine-tuned via its interactors and modifications is...

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Detalles Bibliográficos
Autores principales: Jiang, Hua, Bian, Weixiang, Sui, Yue, Li, Huanle, Zhao, Han, Wang, Wenqi, Li, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491713/
https://www.ncbi.nlm.nih.gov/pubmed/36129980
http://dx.doi.org/10.1126/sciadv.abq4831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491713/
https://www.ncbi.nlm.nih.gov/pubmed/36129980
http://dx.doi.org/10.1126/sciadv.abq4831

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