Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery

Organoids serve as a novel tool for disease modeling in three-dimensional multicellular contexts. Static organoids, however, lack the requisite biophysical microenvironment such as fluid flow, limiting their ability to faithfully recapitulate disease pathology. Here, we unite organoids with organ-on...

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Detalles Bibliográficos
Autores principales: Hiratsuka, Ken, Miyoshi, Tomoya, Kroll, Katharina T., Gupta, Navin R., Valerius, M. Todd, Ferrante, Thomas, Yamashita, Michifumi, Lewis, Jennifer A., Morizane, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491724/
https://www.ncbi.nlm.nih.gov/pubmed/36129975
http://dx.doi.org/10.1126/sciadv.abq0866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491724/
https://www.ncbi.nlm.nih.gov/pubmed/36129975
http://dx.doi.org/10.1126/sciadv.abq0866

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