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Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery
Organoids serve as a novel tool for disease modeling in three-dimensional multicellular contexts. Static organoids, however, lack the requisite biophysical microenvironment such as fluid flow, limiting their ability to faithfully recapitulate disease pathology. Here, we unite organoids with organ-on...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491724/ https://www.ncbi.nlm.nih.gov/pubmed/36129975 http://dx.doi.org/10.1126/sciadv.abq0866 |