Mechanistic insights into global suppressors of protein folding defects

Most amino acid substitutions in a protein either lead to partial loss-of-function or are near neutral. Several studies have shown the existence of second-site mutations that can rescue defects caused by diverse loss-of-function mutations. Such global suppressor mutations are key drivers of protein...

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Detalles Bibliográficos
Autores principales: Chattopadhyay, Gopinath, Bhowmick, Jayantika, Manjunath, Kavyashree, Ahmed, Shahbaz, Goyal, Parveen, Varadarajan, Raghavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491731/
https://www.ncbi.nlm.nih.gov/pubmed/36037221
http://dx.doi.org/10.1371/journal.pgen.1010334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491731/
https://www.ncbi.nlm.nih.gov/pubmed/36037221
http://dx.doi.org/10.1371/journal.pgen.1010334

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