Weak Cation Selectivity in HCN Channels Results From K(+)-Mediated Release of Na(+) From Selectivity Filter Binding Sites

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels generate the pacemaker current which plays an important role in the timing of various biological processes like the heart beat. We used umbrella sampling to explore the potential of mean force for the conduction of potassium and sodi...

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Detalles Bibliográficos
Autores principales: Bauer, Daniel, Wissmann, Jan, Moroni, Anna, Thiel, Gerhard, Hamacher, Kay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492253/
https://www.ncbi.nlm.nih.gov/pubmed/36156894
http://dx.doi.org/10.1093/function/zqac019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492253/
https://www.ncbi.nlm.nih.gov/pubmed/36156894
http://dx.doi.org/10.1093/function/zqac019

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