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Weak Cation Selectivity in HCN Channels Results From K(+)-Mediated Release of Na(+) From Selectivity Filter Binding Sites
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels generate the pacemaker current which plays an important role in the timing of various biological processes like the heart beat. We used umbrella sampling to explore the potential of mean force for the conduction of potassium and sodi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492253/ https://www.ncbi.nlm.nih.gov/pubmed/36156894 http://dx.doi.org/10.1093/function/zqac019 |