Development and structure–activity relationships of tanshinones as selective 11β-hydroxysteroid dehydrogenase 1 inhibitors

11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) represents a promising drug target for metabolic syndrome, including obesity and type 2 diabetes. Our initial screen of a collection of natural products from Danshen led to the identification of tanshinones as the potent and selective 11β-HSD1 inhibitors...

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Detalles Bibliográficos
Autores principales: Deng, Xu, Huang, Su-Ling, Ren, Jian, Pan, Zheng-Hong, Shen, Yu, Zhou, Hao-Feng, Zuo, Zhi-Li, Leng, Ying, Zhao, Qin-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492458/
https://www.ncbi.nlm.nih.gov/pubmed/36131216
http://dx.doi.org/10.1007/s13659-022-00358-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492458/
https://www.ncbi.nlm.nih.gov/pubmed/36131216
http://dx.doi.org/10.1007/s13659-022-00358-9

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