Brain-restricted mTOR inhibition with binary pharmacology

On-target–off-tissue drug engagement is an important source of adverse effects that constrains the therapeutic window of drug candidates(1,2). In diseases of the central nervous system, drugs with brain-restricted pharmacology are highly desirable. Here we report a strategy to achieve inhibition of...

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Detalles Bibliográficos
Autores principales: Zhang, Ziyang, Fan, Qiwen, Luo, Xujun, Lou, Kevin, Weiss, William A., Shokat, Kevan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492542/
https://www.ncbi.nlm.nih.gov/pubmed/36104566
http://dx.doi.org/10.1038/s41586-022-05213-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492542/
https://www.ncbi.nlm.nih.gov/pubmed/36104566
http://dx.doi.org/10.1038/s41586-022-05213-y

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