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Brain-restricted mTOR inhibition with binary pharmacology
On-target–off-tissue drug engagement is an important source of adverse effects that constrains the therapeutic window of drug candidates(1,2). In diseases of the central nervous system, drugs with brain-restricted pharmacology are highly desirable. Here we report a strategy to achieve inhibition of...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492542/ https://www.ncbi.nlm.nih.gov/pubmed/36104566 http://dx.doi.org/10.1038/s41586-022-05213-y |