Intrinsic bias estimation for improved analysis of bulk and single-cell chromatin accessibility profiles using SELMA

Genome-wide profiling of chromatin accessibility by DNase-seq or ATAC-seq has been widely used to identify regulatory DNA elements and transcription factor binding sites. However, enzymatic DNA cleavage exhibits intrinsic sequence biases that confound chromatin accessibility profiling data analysis....

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Detalles Bibliográficos
Autores principales: Hu, Shengen Shawn, Liu, Lin, Li, Qi, Ma, Wenjing, Guertin, Michael J., Meyer, Clifford A., Deng, Ke, Zhang, Tingting, Zang, Chongzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492688/
https://www.ncbi.nlm.nih.gov/pubmed/36130957
http://dx.doi.org/10.1038/s41467-022-33194-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492688/
https://www.ncbi.nlm.nih.gov/pubmed/36130957
http://dx.doi.org/10.1038/s41467-022-33194-z

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