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Intrinsic bias estimation for improved analysis of bulk and single-cell chromatin accessibility profiles using SELMA
Genome-wide profiling of chromatin accessibility by DNase-seq or ATAC-seq has been widely used to identify regulatory DNA elements and transcription factor binding sites. However, enzymatic DNA cleavage exhibits intrinsic sequence biases that confound chromatin accessibility profiling data analysis....
Autores principales: | Hu, Shengen Shawn, Liu, Lin, Li, Qi, Ma, Wenjing, Guertin, Michael J., Meyer, Clifford A., Deng, Ke, Zhang, Tingting, Zang, Chongzhi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492688/ https://www.ncbi.nlm.nih.gov/pubmed/36130957 http://dx.doi.org/10.1038/s41467-022-33194-z |
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