Blockade of PGK1 and ALDOA enhances bilirubin control of Th17 cells in Crohn’s disease

Unconjugated bilirubin (UCB) confers Th17-cells immunosuppressive features by activating aryl-hydrocarbon-receptor, a modulator of toxin and adaptive immune responses. In Crohn’s disease, Th17-cells fail to acquire regulatory properties in response to UCB, remaining at an inflammatory/pathogenic sta...

Descripción completa

Detalles Bibliográficos
Autores principales: Vuerich, Marta, Wang, Na, Graham, Jonathon J., Gao, Li, Zhang, Wei, Kalbasi, Ahmadreza, Zhang, Lina, Csizmadia, Eva, Hristopoulos, Jason, Ma, Yun, Kokkotou, Efi, Cheifetz, Adam S., Robson, Simon C., Longhi, Maria Serena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492699/
https://www.ncbi.nlm.nih.gov/pubmed/36131123
http://dx.doi.org/10.1038/s42003-022-03913-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492699/
https://www.ncbi.nlm.nih.gov/pubmed/36131123
http://dx.doi.org/10.1038/s42003-022-03913-9

Ejemplares similares