Transformation of adenocarcinoma to squamous cell carcinoma as a source of EGFR-TKI resistance: A case report and literature review

In general, non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations respond to tyrosine kinase inhibitors (TKIs). However, most patients experience resistance within 1-2 years after treatment. The histological explanation for the acquired resistance is that maligna...

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Autores principales: Xi, Yun-Zhu, Xie, Li, Tan, Xiao-Wu, Zeng, Sai-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493008/
https://www.ncbi.nlm.nih.gov/pubmed/36158654
http://dx.doi.org/10.3389/fonc.2022.942084
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author Xi, Yun-Zhu
Xie, Li
Tan, Xiao-Wu
Zeng, Sai-Li
author_facet Xi, Yun-Zhu
Xie, Li
Tan, Xiao-Wu
Zeng, Sai-Li
author_sort Xi, Yun-Zhu
collection PubMed
description In general, non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations respond to tyrosine kinase inhibitors (TKIs). However, most patients experience resistance within 1-2 years after treatment. The histological explanation for the acquired resistance is that malignant transformation occurs during cancer treatment. To date, the transformation from adenocarcinoma to squamous cell carcinoma associated with EGFR-TKI use remains poorly reported. We report a case of stage IV lung adenocarcinoma with EGFR mutations that converted to squamous cell carcinoma due to long-term administration of EGFR-TKIs. This report strengthens histological evolution as a source of acquired drug resistance.
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spelling pubmed-94930082022-09-23 Transformation of adenocarcinoma to squamous cell carcinoma as a source of EGFR-TKI resistance: A case report and literature review Xi, Yun-Zhu Xie, Li Tan, Xiao-Wu Zeng, Sai-Li Front Oncol Oncology In general, non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations respond to tyrosine kinase inhibitors (TKIs). However, most patients experience resistance within 1-2 years after treatment. The histological explanation for the acquired resistance is that malignant transformation occurs during cancer treatment. To date, the transformation from adenocarcinoma to squamous cell carcinoma associated with EGFR-TKI use remains poorly reported. We report a case of stage IV lung adenocarcinoma with EGFR mutations that converted to squamous cell carcinoma due to long-term administration of EGFR-TKIs. This report strengthens histological evolution as a source of acquired drug resistance. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9493008/ /pubmed/36158654 http://dx.doi.org/10.3389/fonc.2022.942084 Text en Copyright © 2022 Xi, Xie, Tan and Zeng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xi, Yun-Zhu
Xie, Li
Tan, Xiao-Wu
Zeng, Sai-Li
Transformation of adenocarcinoma to squamous cell carcinoma as a source of EGFR-TKI resistance: A case report and literature review
title Transformation of adenocarcinoma to squamous cell carcinoma as a source of EGFR-TKI resistance: A case report and literature review
title_full Transformation of adenocarcinoma to squamous cell carcinoma as a source of EGFR-TKI resistance: A case report and literature review
title_fullStr Transformation of adenocarcinoma to squamous cell carcinoma as a source of EGFR-TKI resistance: A case report and literature review
title_full_unstemmed Transformation of adenocarcinoma to squamous cell carcinoma as a source of EGFR-TKI resistance: A case report and literature review
title_short Transformation of adenocarcinoma to squamous cell carcinoma as a source of EGFR-TKI resistance: A case report and literature review
title_sort transformation of adenocarcinoma to squamous cell carcinoma as a source of egfr-tki resistance: a case report and literature review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493008/
https://www.ncbi.nlm.nih.gov/pubmed/36158654
http://dx.doi.org/10.3389/fonc.2022.942084
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