Engineering the N-glycosylation pathway of Nicotiana tabacum for molecular pharming using CRISPR/Cas9

Molecular pharming in plants offers exciting possibilities to address global access to modern biologics. However, differences in the N-glycosylation pathway including the presence of β(1,2)-xylose and core α(1,3)-fucose can affect activity, potency and immunogenicity of plant-derived proteins. Succe...

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Detalles Bibliográficos
Autores principales: Göritzer, Kathrin, Grandits, Melanie, Grünwald-Gruber, Clemens, Figl, Rudolf, Mercx, Sébastien, Navarre, Catherine, Ma, Julian K-C., Teh, Audrey Y-H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Plant Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493077/
https://www.ncbi.nlm.nih.gov/pubmed/36161010
http://dx.doi.org/10.3389/fpls.2022.1003065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493077/
https://www.ncbi.nlm.nih.gov/pubmed/36161010
http://dx.doi.org/10.3389/fpls.2022.1003065

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