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Caloric restriction prevents obesity- and intermittent hypoxia-induced cardiac remodeling in leptin-deficient ob/ob mice

Background: Intermittent hypoxia (IH), a key characteristic of obstructive sleep apnea, is independently associated with cardiometabolic impairment. While endogenous leptin levels may provide cardioprotective effects against hypoxia, leptin resistance is common among obese individuals presenting wit...

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Detalles Bibliográficos
Autores principales: Jones, Aaron A., Framnes-DeBoer, Sarah N., Shipp, Arianne, Arble, Deanna M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493268/
https://www.ncbi.nlm.nih.gov/pubmed/36160851
http://dx.doi.org/10.3389/fphys.2022.963762