Drosophila CRISPR/Cas9 mutants as tools to analyse cardiac filamin function and pathogenicity of human FLNC variants

Filamins are large proteins with actin-binding properties. Mutations in FLNC, one of the three filamin genes in humans, have recently been implicated in dominant cardiomyopathies, but the underlying mechanisms are not well understood. Here, we aimed to use Drosophila melanogaster as a new in vivo mo...

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Detalles Bibliográficos
Autores principales: Ader, Flavie, Russi, Maria, Tixier-Cardoso, Laura, Jullian, Estelle, Martin, Elodie, Richard, Pascale, Villard, Eric, Monnier, Veronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493756/
https://www.ncbi.nlm.nih.gov/pubmed/36066120
http://dx.doi.org/10.1242/bio.059376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9493756/
https://www.ncbi.nlm.nih.gov/pubmed/36066120
http://dx.doi.org/10.1242/bio.059376

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