Selection of rAAV vectors that cross the human blood-brain barrier and target the central nervous system using a transwell model

A limitation for recombinant adeno-associated virus (rAAV)-mediated gene transfer into the central nervous system (CNS) is the low penetration of vectors across the human blood-brain barrier (BBB). High doses of intravenously delivered vector are required to reach the CNS, which has resulted in vary...

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Detalles Bibliográficos
Autores principales: Song, Ren, Pekrun, Katja, Khan, Themasap A., Zhang, Feijie, Paşca, Sergiu P., Kay, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494039/
https://www.ncbi.nlm.nih.gov/pubmed/36186955
http://dx.doi.org/10.1016/j.omtm.2022.09.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494039/
https://www.ncbi.nlm.nih.gov/pubmed/36186955
http://dx.doi.org/10.1016/j.omtm.2022.09.002

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