Affinity capillary electrophoresis – mass spectrometry permits direct binding assessment of IgG and FcγRIIa in a glycoform-resolved manner

The impact of antibody glycoforms on FcγRIIa activation and immune responses is poorly understood. Yet, glycoform binding assessment remains one of the major analytical challenges requiring long enrichment or glycoengineering steps. Here, we developed and applied an affinity capillary electrophoresi...

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Detalles Bibliográficos
Autores principales: Gstöttner, Christoph, Knaupp, Alexander, Vidarsson, Gestur, Reusch, Dietmar, Schlothauer, Tilman, Wuhrer, Manfred, Domínguez-Vega, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494200/
https://www.ncbi.nlm.nih.gov/pubmed/36159782
http://dx.doi.org/10.3389/fimmu.2022.980291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494200/
https://www.ncbi.nlm.nih.gov/pubmed/36159782
http://dx.doi.org/10.3389/fimmu.2022.980291

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