Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity

BACKGROUND: Alzheimer’s Disease (AD) affects millions globally, but therapy development is lagging. New experimental systems that monitor neuronal functions in conditions approximating the AD brain may be beneficial for identifying new therapeutic strategies. METHODS: We expose cultured neurons to a...

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Detalles Bibliográficos
Autores principales: Hsieh, Yi-Chen, Negri, Joseph, He, Amy, Pearse, Richard V., Liu, Lei, Duong, Duc M., Chibnik, Lori B., Bennett, David A., Seyfried, Nicholas T., Young-Pearse, Tracy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494921/
https://www.ncbi.nlm.nih.gov/pubmed/36131294
http://dx.doi.org/10.1186/s13024-022-00558-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494921/
https://www.ncbi.nlm.nih.gov/pubmed/36131294
http://dx.doi.org/10.1186/s13024-022-00558-4

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