New MraY(AA) Inhibitors with an Aminoribosyl Uridine Structure and an Oxadiazole

New inhibitors of the bacterial transferase MraY from Aquifex aeolicus (MraY(AA)), based on the aminoribosyl uridine central core of known natural MraY inhibitors, have been designed to generate interaction of their oxadiazole linker with the key amino acids (H324 or H325) of the enzyme active site,...

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Detalles Bibliográficos
Autores principales: Wan, Hongwei, Ben Othman, Raja, Le Corre, Laurent, Poinsot, Mélanie, Oliver, Martin, Amoroso, Ana, Joris, Bernard, Touzé, Thierry, Auger, Rodolphe, Calvet-Vitale, Sandrine, Bosco, Michaël, Gravier-Pelletier, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495235/
https://www.ncbi.nlm.nih.gov/pubmed/36139968
http://dx.doi.org/10.3390/antibiotics11091189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495235/
https://www.ncbi.nlm.nih.gov/pubmed/36139968
http://dx.doi.org/10.3390/antibiotics11091189

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