Kanamycin and Cisplatin Ototoxicity: Differences in Patterns of Oxidative Stress, Antioxidant Enzyme Expression and Hair Cell Loss in the Cochlea

Kanamycin and cisplatin are ototoxic drugs. The mechanisms are incompletely known. With subcutaneous kanamycin (400 mg/kg, 15 days), auditory threshold shifts were detected at days 12–13 at 16 and 32 kHz, extending to 8 and 4 kHz at days 14–15. The outer hair cell (OHC) loss was concentrated past da...

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Detalles Bibliográficos
Autores principales: Gibaja, Alejandro, Alvarado, Juan C., Scheper, Verena, Carles, Liliana, Juiz, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495324/
https://www.ncbi.nlm.nih.gov/pubmed/36139833
http://dx.doi.org/10.3390/antiox11091759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495324/
https://www.ncbi.nlm.nih.gov/pubmed/36139833
http://dx.doi.org/10.3390/antiox11091759

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