LRRK2 Inhibition by PF06447475 Antagonist Modulates Early Neuronal Damage after Spinal Cord Trauma

Spinal cord injury (SCI) is a devastating event followed by neurodegeneration, activation of the inflammatory cascade, and immune system. The leucine-rich-repeat kinase 2 (LRRK2) is a gene associated with Parkinson’s disease (PD), moreover, its kinase activity was found to be upregulated after insti...

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Detalles Bibliográficos
Autores principales: Filippone, Alessia, Mannino, Deborah, Cucinotta, Laura, Paterniti, Irene, Esposito, Emanuela, Campolo, Michela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495377/
https://www.ncbi.nlm.nih.gov/pubmed/36139708
http://dx.doi.org/10.3390/antiox11091634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495377/
https://www.ncbi.nlm.nih.gov/pubmed/36139708
http://dx.doi.org/10.3390/antiox11091634

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