Identification of the Natural Steroid Sapogenin Diosgenin as a Direct Dual-Specific RORα/γ Inverse Agonist

The steroid sapogenin diosgenin is a well-known natural product with a plethora of described pharmacological activities including the amelioration of T helper 17 (Th17)-driven pathologies. However, the exact underlying mode of action of diosgenin leading to a dampened Th17 response is still largely...

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Detalles Bibliográficos
Autores principales: Schwarz, Patrik F., Perhal, Alexander F., Schöberl, Lucia N., Kraus, Martin M., Kirchmair, Johannes, Dirsch, Verena M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495423/
https://www.ncbi.nlm.nih.gov/pubmed/36140177
http://dx.doi.org/10.3390/biomedicines10092076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495423/
https://www.ncbi.nlm.nih.gov/pubmed/36140177
http://dx.doi.org/10.3390/biomedicines10092076

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