Cargando…
Icariside II Exerts Anti-Type 2 Diabetic Effect by Targeting PPARα/γ: Involvement of ROS/NF-κB/IRS1 Signaling Pathway
Type 2 diabetes mellitus (T2DM) is a multisystem and complex metabolic disorder which is associated with insulin resistance and impairments of pancreatic β-cells. Previous studies have shown that icariside II (ICS II), one of the main active ingredients of Herba Epimedii, exerts potent anti-inflamma...
Autores principales: | Li, Yiqi, Li, Yeli, Chen, Nana, Feng, Linying, Gao, Jianmei, Zeng, Nan, He, Zhixu, Gong, Qihai |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495514/ https://www.ncbi.nlm.nih.gov/pubmed/36139776 http://dx.doi.org/10.3390/antiox11091705 |
Ejemplares similares
-
Icariside II, a Naturally Occurring SIRT3 Agonist, Protects against Myocardial Infarction through the AMPK/PGC-1α/Apoptosis Signaling Pathway
por: Li, Yeli, et al.
Publicado: (2022) -
Icariside II Ameliorates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Inhibiting the Amyloidogenic Pathway: Involvement of BDNF/TrkB/CREB Signaling and Up-Regulation of PPARα and PPARγ in Rats
por: Yin, Caixia, et al.
Publicado: (2018) -
Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischaemia/reperfusion injury by inhibiting glycogen synthase kinase‐3β‐mediated activation of autophagy
por: Gao, Jianmei, et al.
Publicado: (2020) -
Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer’s Disease Model Mice Targeting Beta-Amyloid Production
por: Yan, Lingli, et al.
Publicado: (2017) -
Early modulation of macrophage ROS-PPARγ-NF-κB signalling by sonodynamic therapy attenuates neointimal hyperplasia in rabbits
por: Yao, Jianting, et al.
Publicado: (2020)