Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction

Mitochondrial dysfunction and oxidative stress are major contributors to the pathophysiology of neurodegenerative diseases, including Alzheimer’s disease (AD). However, the mechanisms driving mitochondrial dysfunction and oxidative stress are unclear. Familial AD (fAD) is an early onset form of AD c...

Descripción completa

Detalles Bibliográficos
Autores principales: Ryan, Kerry C., Laboy, Jocelyn T., Norman, Kenneth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495597/
https://www.ncbi.nlm.nih.gov/pubmed/36139715
http://dx.doi.org/10.3390/antiox11091642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495597/
https://www.ncbi.nlm.nih.gov/pubmed/36139715
http://dx.doi.org/10.3390/antiox11091642

Ejemplares similares