Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

SIMPLE SUMMARY: Prion diseases are neurodegenerative disorders caused by the amyloidal aggregation of the cellular prion protein. We apply single-molecule force spectroscopy approaches to study the unfolding of prion protein monomers and dimers in different orientations. We find heterogeneous behavi...

Descripción completa

Detalles Bibliográficos
Autores principales: Raspadori, Andrea, Vignali, Valentina, Murello, Anna, Giachin, Gabriele, Samorì, Bruno, Tanaka, Motomasa, Bustamante, Carlos, Zuccheri, Giampaolo, Legname, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495685/
https://www.ncbi.nlm.nih.gov/pubmed/36138837
http://dx.doi.org/10.3390/biology11091358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495685/
https://www.ncbi.nlm.nih.gov/pubmed/36138837
http://dx.doi.org/10.3390/biology11091358

Ejemplares similares