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Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy

SIMPLE SUMMARY: Prion diseases are neurodegenerative disorders caused by the amyloidal aggregation of the cellular prion protein. We apply single-molecule force spectroscopy approaches to study the unfolding of prion protein monomers and dimers in different orientations. We find heterogeneous behavi...

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Detalles Bibliográficos
Autores principales:	Raspadori, Andrea, Vignali, Valentina, Murello, Anna, Giachin, Gabriele, Samorì, Bruno, Tanaka, Motomasa, Bustamante, Carlos, Zuccheri, Giampaolo, Legname, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495685/ https://www.ncbi.nlm.nih.gov/pubmed/36138837 http://dx.doi.org/10.3390/biology11091358

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