Knockout and Inhibition of Ape1: Roles of Ape1 in Base Excision DNA Repair and Modulation of Gene Expression

Apurinic/apyrimidinic endonuclease 1/redox effector-1 (Ape1/Ref-1) is the major apurinic/apyrimidinic (AP) endonuclease in mammalian cells. It functions mainly in the base excision repair pathway to create a suitable substrate for DNA polymerases. Human Ape1 protein can activate some transcription f...

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Detalles Bibliográficos
Autores principales: Xue, Zhouyiyuan, Demple, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495735/
https://www.ncbi.nlm.nih.gov/pubmed/36139891
http://dx.doi.org/10.3390/antiox11091817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495735/
https://www.ncbi.nlm.nih.gov/pubmed/36139891
http://dx.doi.org/10.3390/antiox11091817

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