Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway

Chelerythrine (CHE) is a majorly harmful isoquinoline alkaloid ingredient in Chelidonium majus that could trigger potential hepatotoxicity, but the pivotal molecular mechanisms remain largely unknown. In the present study, CHE-induced cytotoxicity and the underlying toxic mechanisms were investigate...

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Detalles Bibliográficos
Autores principales: Lin, Yanling, Zhang, Qinzhi, Xie, Baofu, Jiang, Haiyang, Shen, Jianzhong, Tang, Shusheng, Dai, Chongshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495744/
https://www.ncbi.nlm.nih.gov/pubmed/36139911
http://dx.doi.org/10.3390/antiox11091837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495744/
https://www.ncbi.nlm.nih.gov/pubmed/36139911
http://dx.doi.org/10.3390/antiox11091837

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