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Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway
Chelerythrine (CHE) is a majorly harmful isoquinoline alkaloid ingredient in Chelidonium majus that could trigger potential hepatotoxicity, but the pivotal molecular mechanisms remain largely unknown. In the present study, CHE-induced cytotoxicity and the underlying toxic mechanisms were investigate...
Autores principales: | Lin, Yanling, Zhang, Qinzhi, Xie, Baofu, Jiang, Haiyang, Shen, Jianzhong, Tang, Shusheng, Dai, Chongshan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495744/ https://www.ncbi.nlm.nih.gov/pubmed/36139911 http://dx.doi.org/10.3390/antiox11091837 |
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