Sequential Accumulation of ‘Driver’ Pathway Mutations Induces the Upregulation of Hydrogen-Sulfide-Producing Enzymes in Human Colonic Epithelial Cell Organoids

Recently, a CRISPR-Cas9 genome-editing system was developed with introduced sequential ‘driver’ mutations in the WNT, MAPK, TGF-β, TP53 and PI3K pathways into organoids derived from normal human intestinal epithelial cells. Prior studies have demonstrated that isogenic organoids harboring mutations...

Descripción completa

Detalles Bibliográficos
Autores principales: Ascenção, Kelly, Dilek, Nahzli, Zuhra, Karim, Módis, Katalin, Sato, Toshiro, Szabo, Csaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495861/
https://www.ncbi.nlm.nih.gov/pubmed/36139896
http://dx.doi.org/10.3390/antiox11091823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495861/
https://www.ncbi.nlm.nih.gov/pubmed/36139896
http://dx.doi.org/10.3390/antiox11091823

Ejemplares similares