The Gelatinase Inhibitor ACT-03 Reduces Gliosis in the Rapid Kindling Rat Model of Epilepsy, and Attenuates Inflammation and Loss of Barrier Integrity In Vitro

Matrix metalloproteinases (MMPs) are endopeptidases responsible for the cleavage of intra- and extracellular proteins. Several brain MMPs have been implicated in neurological disorders including epilepsy. We recently showed that the novel gelatinase inhibitor ACT-03 has disease-modifying effects in...

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Detalles Bibliográficos
Autores principales: Broekaart, Diede W. M., Zimmer, Till S., Cohen, Sophie T., Tessers, Rianne, Anink, Jasper J., de Vries, Helga E., Gorter, Jan A., Prades, Roger, Aronica, Eleonora, van Vliet, Erwin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495904/
https://www.ncbi.nlm.nih.gov/pubmed/36140216
http://dx.doi.org/10.3390/biomedicines10092117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495904/
https://www.ncbi.nlm.nih.gov/pubmed/36140216
http://dx.doi.org/10.3390/biomedicines10092117

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