Cargando…
MiR-223 and MiR-186 Are Associated with Long-Term Mortality after Myocardial Infarction
Background—The identification and stratification of patients at risk of fatal outcomes after myocardial infarction (MI) is of considerable interest to guide secondary prevention therapies. Currently, no accurate biomarkers are available to identify subjects who are at risk of suffering acute manifes...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496068/ https://www.ncbi.nlm.nih.gov/pubmed/36139082 http://dx.doi.org/10.3390/biom12091243 |
_version_ | 1784794177684373504 |
---|---|
author | Elbaz, Meyer Faccini, Julien Laperche, Clémence Grazide, Marie-Hélène Ruidavets, Jean-Bernard Vindis, Cécile |
author_facet | Elbaz, Meyer Faccini, Julien Laperche, Clémence Grazide, Marie-Hélène Ruidavets, Jean-Bernard Vindis, Cécile |
author_sort | Elbaz, Meyer |
collection | PubMed |
description | Background—The identification and stratification of patients at risk of fatal outcomes after myocardial infarction (MI) is of considerable interest to guide secondary prevention therapies. Currently, no accurate biomarkers are available to identify subjects who are at risk of suffering acute manifestations of coronary heart disease as well as to predict adverse events after MI. Non-coding circulating microRNAs (miRNAs) have been proposed as novel diagnostic and prognostic biomarkers in cardiovascular diseases. The aims of the study were to investigate the clinical value of a panel of circulating miRNAs as accurate biomarkers associated with MI and mortality risk prediction in patients with documented MI. Methods and Results—seven circulating plasma miRNAs were analyzed in 67 MI patients and 80 control subjects at a high cardiovascular risk but without known coronary diseases. Multivariate logistic regression analyses demonstrated that six miRNAs were independently associated with MI occurrence. Among them, miR-223 and miR-186 reliably predicted long-term mortality in MI patients, in particular miR-223 (HR 1.57 per one-unit increase, p = 0.02), after left ventricular ejection fraction (LVEF) adjustment. Kaplan–Meier survival analyses provided a predictive threshold value of miR-223 expression (p = 0.028) for long-term mortality. Conclusions—Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI. |
format | Online Article Text |
id | pubmed-9496068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94960682022-09-23 MiR-223 and MiR-186 Are Associated with Long-Term Mortality after Myocardial Infarction Elbaz, Meyer Faccini, Julien Laperche, Clémence Grazide, Marie-Hélène Ruidavets, Jean-Bernard Vindis, Cécile Biomolecules Article Background—The identification and stratification of patients at risk of fatal outcomes after myocardial infarction (MI) is of considerable interest to guide secondary prevention therapies. Currently, no accurate biomarkers are available to identify subjects who are at risk of suffering acute manifestations of coronary heart disease as well as to predict adverse events after MI. Non-coding circulating microRNAs (miRNAs) have been proposed as novel diagnostic and prognostic biomarkers in cardiovascular diseases. The aims of the study were to investigate the clinical value of a panel of circulating miRNAs as accurate biomarkers associated with MI and mortality risk prediction in patients with documented MI. Methods and Results—seven circulating plasma miRNAs were analyzed in 67 MI patients and 80 control subjects at a high cardiovascular risk but without known coronary diseases. Multivariate logistic regression analyses demonstrated that six miRNAs were independently associated with MI occurrence. Among them, miR-223 and miR-186 reliably predicted long-term mortality in MI patients, in particular miR-223 (HR 1.57 per one-unit increase, p = 0.02), after left ventricular ejection fraction (LVEF) adjustment. Kaplan–Meier survival analyses provided a predictive threshold value of miR-223 expression (p = 0.028) for long-term mortality. Conclusions—Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI. MDPI 2022-09-06 /pmc/articles/PMC9496068/ /pubmed/36139082 http://dx.doi.org/10.3390/biom12091243 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Elbaz, Meyer Faccini, Julien Laperche, Clémence Grazide, Marie-Hélène Ruidavets, Jean-Bernard Vindis, Cécile MiR-223 and MiR-186 Are Associated with Long-Term Mortality after Myocardial Infarction |
title | MiR-223 and MiR-186 Are Associated with Long-Term Mortality after Myocardial Infarction |
title_full | MiR-223 and MiR-186 Are Associated with Long-Term Mortality after Myocardial Infarction |
title_fullStr | MiR-223 and MiR-186 Are Associated with Long-Term Mortality after Myocardial Infarction |
title_full_unstemmed | MiR-223 and MiR-186 Are Associated with Long-Term Mortality after Myocardial Infarction |
title_short | MiR-223 and MiR-186 Are Associated with Long-Term Mortality after Myocardial Infarction |
title_sort | mir-223 and mir-186 are associated with long-term mortality after myocardial infarction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496068/ https://www.ncbi.nlm.nih.gov/pubmed/36139082 http://dx.doi.org/10.3390/biom12091243 |
work_keys_str_mv | AT elbazmeyer mir223andmir186areassociatedwithlongtermmortalityaftermyocardialinfarction AT faccinijulien mir223andmir186areassociatedwithlongtermmortalityaftermyocardialinfarction AT lapercheclemence mir223andmir186areassociatedwithlongtermmortalityaftermyocardialinfarction AT grazidemariehelene mir223andmir186areassociatedwithlongtermmortalityaftermyocardialinfarction AT ruidavetsjeanbernard mir223andmir186areassociatedwithlongtermmortalityaftermyocardialinfarction AT vindiscecile mir223andmir186areassociatedwithlongtermmortalityaftermyocardialinfarction |