Plasma Kallikrein-Activated TGF-β Is Prognostic for Poor Overall Survival in Patients with Pancreatic Ductal Adenocarcinoma and Associates with Increased Fibrogenesis

Pancreatic ductal adenocarcinoma (PDAC) is a hard-to-treat cancer due to the collagen-rich (fibrotic) and immune-suppressed microenvironment. A major driver of this phenomenon is transforming growth factor beta (TGF-β). TGF-β is produced in an inactive complex with a latency-associated protein (LAP)...

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Detalles Bibliográficos
Autores principales: Pedersen, Rasmus S., Nissen, Neel I., Jensen, Christina, Thorlacius-Ussing, Jeppe, Manon-Jensen, Tina, Olesen, Majken L., Langholm, Lasse L., Diab, Hadi M. H., Jorgensen, Lars N., Hansen, Carsten P., Chen, Inna M., Johansen, Julia S., Karsdal, Morten A., Willumsen, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496221/
https://www.ncbi.nlm.nih.gov/pubmed/36139154
http://dx.doi.org/10.3390/biom12091315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496221/
https://www.ncbi.nlm.nih.gov/pubmed/36139154
http://dx.doi.org/10.3390/biom12091315

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