Cargando…

Plasma Kallikrein-Activated TGF-β Is Prognostic for Poor Overall Survival in Patients with Pancreatic Ductal Adenocarcinoma and Associates with Increased Fibrogenesis

Pancreatic ductal adenocarcinoma (PDAC) is a hard-to-treat cancer due to the collagen-rich (fibrotic) and immune-suppressed microenvironment. A major driver of this phenomenon is transforming growth factor beta (TGF-β). TGF-β is produced in an inactive complex with a latency-associated protein (LAP)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pedersen, Rasmus S., Nissen, Neel I., Jensen, Christina, Thorlacius-Ussing, Jeppe, Manon-Jensen, Tina, Olesen, Majken L., Langholm, Lasse L., Diab, Hadi M. H., Jorgensen, Lars N., Hansen, Carsten P., Chen, Inna M., Johansen, Julia S., Karsdal, Morten A., Willumsen, Nicholas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496221/ https://www.ncbi.nlm.nih.gov/pubmed/36139154 http://dx.doi.org/10.3390/biom12091315

Ejemplares similares

High serum levels of the C-propetide of type V collagen (PRO-C5) are prognostic for short overall survival in patients with pancreatic ductal adenocarcinoma
por: Nissen, Neel I., et al.
Publicado: (2023)

Type XX Collagen Is Elevated in Circulation of Patients with Solid Tumors
por: Thorlacius-Ussing, Jeppe, et al.
Publicado: (2022)

Type XXII Collagen Complements Fibrillar Collagens in the Serological Assessment of Tumor Fibrosis and the Outcome in Pancreatic Cancer
por: Madsen, Emilie A., et al.
Publicado: (2022)

Levels of type XVII collagen (BP180) ectodomain are elevated in circulation from patients with multiple cancer types and is prognostic for patients with metastatic colorectal cancer
por: Crespo-Bravo, Marina, et al.
Publicado: (2023)

Serum Type XIX Collagen is Significantly Elevated in Non-Small Cell Lung Cancer: A Preliminary Study on Biomarker Potential
por: Thorlacius-Ussing, Jeppe, et al.
Publicado: (2020)

Autoreactivity against Denatured Type III Collagen Is Significantly Decreased in Serum from Patients with Cancer Compared to Healthy Controls
por: Jensen, Christina, et al.
Publicado: (2023)

Collagen Biomarkers Quantify Fibroblast Activity In Vitro and Predict Survival in Patients with Pancreatic Ductal Adenocarcinoma
por: Nissen, Neel I., et al.
Publicado: (2022)

Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort
por: Rønnow, Sarah Rank, et al.
Publicado: (2019)

Preliminary investigation of elevated collagen and blood‐clotting markers as potential noninvasive biomarkers for small cell lung cancer
por: Thorlacius‐Ussing, Jeppe, et al.
Publicado: (2023)

Serological assessment of collagen fragments and tumor fibrosis may guide immune checkpoint inhibitor therapy
por: Jensen, Christina, et al.
Publicado: (2021)

Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology
por: Nissen, Neel I., et al.
Publicado: (2019)

Post-translational modifications of vimentin reflect different pathological processes associated with non-small cell lung cancer and chronic obstructive pulmonary disease
por: Nissen, Neel Ingemann, et al.
Publicado: (2019)

In Contrast to Anti-CCP, MMP-Degraded and Citrullinated Vimentin (VICM) Is Both a Diagnostic and a Treatment Response Biomarker
por: Drobinski, Patryk J., et al.
Publicado: (2022)

Lot-to-Lot Variance in Immunoassays—Causes, Consequences, and Solutions
por: Luo, Yunyun, et al.
Publicado: (2023)

Prognostic value of blood-based fibrosis biomarkers in patients with metastatic colorectal cancer receiving chemotherapy and bevacizumab
por: Nissen, Neel I., et al.
Publicado: (2021)

Type IV collagen turnover is predictive of mortality in COPD: a comparison to fibrinogen in a prospective analysis of the ECLIPSE cohort
por: Rønnow, Sarah Rank, et al.
Publicado: (2019)

Combining biomarkers of clot resolution and alveolar basement membrane destruction predicts mortality in the ECLIPSE COPD cohort
por: Sand, Jannie M.B., et al.
Publicado: (2020)

Endotrophin, an extracellular hormone, in combination with neoepitope markers of von Willebrand factor improves prediction of mortality in the ECLIPSE COPD cohort
por: Rønnow, Sarah R., et al.
Publicado: (2020)

Increased von Willebrand Factor Processing in COPD, Reflecting Lung Epithelium Damage, Is Associated with Emphysema, Exacerbations and Elevated Mortality Risk
por: Langholm, Lasse L, et al.
Publicado: (2020)

Procollagen type I N-terminal propeptide (PINP) is a marker for fibrogenesis in bile duct ligation-induced fibrosis in rats
por: Veidal, Sanne Skovgård, et al.
Publicado: (2010)

Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma
por: Candido, Juliana B., et al.
Publicado: (2021)

Tumstatin, a Matrikine Derived from Collagen Type IVα3, is Elevated in Serum from Patients with Non–Small Cell Lung Cancer
por: Nielsen, Signe Holm, et al.
Publicado: (2018)

Fibrogenesis
por: Harington, J. S.
Publicado: (1974)

Fibrogenesis
por: Munger, John S., et al.
Publicado: (2010)

Blood-based extracellular matrix biomarkers as predictors of survival in patients with metastatic pancreatic ductal adenocarcinoma receiving pegvorhyaluronidase alfa
por: Wang, Song, et al.
Publicado: (2021)

Endotrophin and C6Ma3, serological biomarkers of type VI collagen remodelling, reflect endoscopic and clinical disease activity in IBD
por: Lindholm, Majken, et al.
Publicado: (2021)

Proteomic Characterization of Colorectal Cancer Tissue from Patients Identifies Novel Putative Protein Biomarkers
por: Ludvigsen, Maja, et al.
Publicado: (2021)

Regulation of tumor immunity and immunotherapy by the tumor collagen extracellular matrix
por: Flies, Dallas B., et al.
Publicado: (2023)

Promoter hypermethylation of SFRP1 as a prognostic and potentially predictive blood-based biomarker in patients with localized pancreatic ductal adenocarcinoma
por: Stubbe, Benjamin Emil, et al.
Publicado: (2023)

Cell-Free DNA Methylation as Blood-Based Biomarkers for Pancreatic Adenocarcinoma—A Literature Update
por: Henriksen, Stine Dam, et al.
Publicado: (2021)

Proteomic Characterization of Colorectal Cancer Cells versus Normal-Derived Colon Mucosa Cells: Approaching Identification of Novel Diagnostic Protein Biomarkers in Colorectal Cancer
por: Ludvigsen, Maja, et al.
Publicado: (2020)

Housefly (Musca domestica L.) associated microbiota across different life stages
por: de Jonge, Nadieh, et al.
Publicado: (2020)

3D printed skulls in court — a benefit to stakeholders?
por: Henningsen, Mikkel Jon, et al.
Publicado: (2023)

Nidogen-1 Degraded by Cathepsin S can be Quantified in Serum and is Associated with Non–Small Cell Lung Cancer
por: Willumsen, Nicholas, et al.
Publicado: (2017)

Fibrotic activity quantified in serum by measurements of type III collagen pro-peptides can be used for prognosis across different solid tumor types
por: Willumsen, Nicholas, et al.
Publicado: (2022)

MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma
por: Oto, Julia, et al.
Publicado: (2020)

Circulating Protein Biomarkers for Prognostic Use in Patients with Advanced Pancreatic Ductal Adenocarcinoma Undergoing Chemotherapy
por: Lindgaard, Sidsel C., et al.
Publicado: (2022)

Welcome to Fibrogenesis & Tissue Repair
por: Pinzani, Massimo
Publicado: (2008)

Role of redoximiRs in fibrogenesis
por: Fierro-Fernández, Marta, et al.
Publicado: (2015)

Mast Cells in Liver Fibrogenesis
por: Weiskirchen, Ralf, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_pf7mr1l0m9ph5hit3f3h7mkttj