Freezing of Gait in Parkinson’s Disease Patients Treated with Bilateral Subthalamic Nucleus Deep Brain Stimulation: A Long-Term Overview
Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment in advanced Parkinson’s Disease (PD). However, the effects of STN-DBS on freezing of gait (FOG) are still debated, particularly in the long-term follow-up (≥5-years). The main aim of the current study is to eval...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496255/ https://www.ncbi.nlm.nih.gov/pubmed/36140318 http://dx.doi.org/10.3390/biomedicines10092214 |
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author | Di Rauso, Giulia Cavallieri, Francesco Campanini, Isabella Gessani, Annalisa Fioravanti, Valentina Feletti, Alberto Damiano, Benedetta Scaltriti, Sara Bardi, Elisa Corni, Maria Giulia Antonelli, Francesca Rispoli, Vittorio Cavalleri, Francesca Molinari, Maria Angela Contardi, Sara Menozzi, Elisa Puzzolante, Annette Rossi, Jessica Meletti, Stefano Biagini, Giuseppe Pavesi, Giacomo Fraix, Valerie Lusuardi, Mirco Fraternali, Alessandro Versari, Annibale Budriesi, Carla Moro, Elena Merlo, Andrea Valzania, Franco |
author_facet | Di Rauso, Giulia Cavallieri, Francesco Campanini, Isabella Gessani, Annalisa Fioravanti, Valentina Feletti, Alberto Damiano, Benedetta Scaltriti, Sara Bardi, Elisa Corni, Maria Giulia Antonelli, Francesca Rispoli, Vittorio Cavalleri, Francesca Molinari, Maria Angela Contardi, Sara Menozzi, Elisa Puzzolante, Annette Rossi, Jessica Meletti, Stefano Biagini, Giuseppe Pavesi, Giacomo Fraix, Valerie Lusuardi, Mirco Fraternali, Alessandro Versari, Annibale Budriesi, Carla Moro, Elena Merlo, Andrea Valzania, Franco |
author_sort | Di Rauso, Giulia |
collection | PubMed |
description | Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment in advanced Parkinson’s Disease (PD). However, the effects of STN-DBS on freezing of gait (FOG) are still debated, particularly in the long-term follow-up (≥5-years). The main aim of the current study is to evaluate the long-term effects of STN-DBS on FOG. Twenty STN-DBS treated PD patients were included. Each patient was assessed before surgery through a detailed neurological evaluation, including FOG score, and revaluated in the long-term (median follow-up: 5-years) in different stimulation and drug conditions. In the long term follow-up, FOG score significantly worsened in the off-stimulation/off-medication condition compared with the pre-operative off-medication assessment (z = −1.930; p = 0.05) but not in the on-stimulation/off-medication (z = −0.357; p = 0.721). There was also a significant improvement of FOG at long-term assessment by comparing on-stimulation/off-medication and off-stimulation/off-medication conditions (z = −2.944; p = 0.003). These results highlight the possible beneficial long-term effects of STN-DBS on FOG. |
format | Online Article Text |
id | pubmed-9496255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94962552022-09-23 Freezing of Gait in Parkinson’s Disease Patients Treated with Bilateral Subthalamic Nucleus Deep Brain Stimulation: A Long-Term Overview Di Rauso, Giulia Cavallieri, Francesco Campanini, Isabella Gessani, Annalisa Fioravanti, Valentina Feletti, Alberto Damiano, Benedetta Scaltriti, Sara Bardi, Elisa Corni, Maria Giulia Antonelli, Francesca Rispoli, Vittorio Cavalleri, Francesca Molinari, Maria Angela Contardi, Sara Menozzi, Elisa Puzzolante, Annette Rossi, Jessica Meletti, Stefano Biagini, Giuseppe Pavesi, Giacomo Fraix, Valerie Lusuardi, Mirco Fraternali, Alessandro Versari, Annibale Budriesi, Carla Moro, Elena Merlo, Andrea Valzania, Franco Biomedicines Article Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment in advanced Parkinson’s Disease (PD). However, the effects of STN-DBS on freezing of gait (FOG) are still debated, particularly in the long-term follow-up (≥5-years). The main aim of the current study is to evaluate the long-term effects of STN-DBS on FOG. Twenty STN-DBS treated PD patients were included. Each patient was assessed before surgery through a detailed neurological evaluation, including FOG score, and revaluated in the long-term (median follow-up: 5-years) in different stimulation and drug conditions. In the long term follow-up, FOG score significantly worsened in the off-stimulation/off-medication condition compared with the pre-operative off-medication assessment (z = −1.930; p = 0.05) but not in the on-stimulation/off-medication (z = −0.357; p = 0.721). There was also a significant improvement of FOG at long-term assessment by comparing on-stimulation/off-medication and off-stimulation/off-medication conditions (z = −2.944; p = 0.003). These results highlight the possible beneficial long-term effects of STN-DBS on FOG. MDPI 2022-09-07 /pmc/articles/PMC9496255/ /pubmed/36140318 http://dx.doi.org/10.3390/biomedicines10092214 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Di Rauso, Giulia Cavallieri, Francesco Campanini, Isabella Gessani, Annalisa Fioravanti, Valentina Feletti, Alberto Damiano, Benedetta Scaltriti, Sara Bardi, Elisa Corni, Maria Giulia Antonelli, Francesca Rispoli, Vittorio Cavalleri, Francesca Molinari, Maria Angela Contardi, Sara Menozzi, Elisa Puzzolante, Annette Rossi, Jessica Meletti, Stefano Biagini, Giuseppe Pavesi, Giacomo Fraix, Valerie Lusuardi, Mirco Fraternali, Alessandro Versari, Annibale Budriesi, Carla Moro, Elena Merlo, Andrea Valzania, Franco Freezing of Gait in Parkinson’s Disease Patients Treated with Bilateral Subthalamic Nucleus Deep Brain Stimulation: A Long-Term Overview |
title | Freezing of Gait in Parkinson’s Disease Patients Treated with Bilateral Subthalamic Nucleus Deep Brain Stimulation: A Long-Term Overview |
title_full | Freezing of Gait in Parkinson’s Disease Patients Treated with Bilateral Subthalamic Nucleus Deep Brain Stimulation: A Long-Term Overview |
title_fullStr | Freezing of Gait in Parkinson’s Disease Patients Treated with Bilateral Subthalamic Nucleus Deep Brain Stimulation: A Long-Term Overview |
title_full_unstemmed | Freezing of Gait in Parkinson’s Disease Patients Treated with Bilateral Subthalamic Nucleus Deep Brain Stimulation: A Long-Term Overview |
title_short | Freezing of Gait in Parkinson’s Disease Patients Treated with Bilateral Subthalamic Nucleus Deep Brain Stimulation: A Long-Term Overview |
title_sort | freezing of gait in parkinson’s disease patients treated with bilateral subthalamic nucleus deep brain stimulation: a long-term overview |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496255/ https://www.ncbi.nlm.nih.gov/pubmed/36140318 http://dx.doi.org/10.3390/biomedicines10092214 |
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