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Metoprolol Inhibits Developmental Brain Sterol Biosynthesis in Mice

De novo sterol synthesis is a critical homeostatic mechanism in the brain that begins during early embryonic development and continues throughout life. Multiple medications have sterol-biosynthesis-inhibiting side effects, with potentially detrimental effects on brain health. Using LC-MS/MS, we inve...

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Detalles Bibliográficos
Autores principales: Allen, Luke B., Mirnics, Károly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496459/
https://www.ncbi.nlm.nih.gov/pubmed/36139049
http://dx.doi.org/10.3390/biom12091211