LRRK2 Deficiency Aggravates Sleep Deprivation-Induced Cognitive Loss by Perturbing Synaptic Pruning in Mice

Mutations of the leucine-rich repeat kinase 2 (LRRK2) gene are associated with pronounced sleep disorders or cognitive dysfunction in neurodegenerative diseases. However, the effects of LRRK2 deficiency on sleep rhythms and sleep deprivation-related cognitive changes, and the relevant underlying mec...

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Detalles Bibliográficos
Autores principales: Cheng, Xiaojuan, Wu, Xilin, Zhang, Yuying, Li, Weian, Feng, Linjuan, You, Hanlin, Yang, Siyu, Yang, Dongping, Chen, Xiaochun, Pan, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496729/
https://www.ncbi.nlm.nih.gov/pubmed/36138936
http://dx.doi.org/10.3390/brainsci12091200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496729/
https://www.ncbi.nlm.nih.gov/pubmed/36138936
http://dx.doi.org/10.3390/brainsci12091200

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