Direct Comparison of HPV16 Viral Genomic Integration, Copy Loss, and Structural Variants in Oropharyngeal and Uterine Cervical Cancers Reveal Distinct Relationships to E2 Disruption and Somatic Alteration

SIMPLE SUMMARY: HPV16 causes approximately 60% of uterine cervical cancer and 95% of HPV-driven oropharynx cancers. Despite both being HPV-associated, these tumors are very different. We directly compare integration of the HPV16 genome into the human genome in these two diseases, finding that the vi...

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Detalles Bibliográficos
Autores principales: Schrank, Travis P., Kim, Sulgi, Rehmani, Hina, Kothari, Aditi, Wu, Di, Yarbrough, Wendell G., Issaeva, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496734/
https://www.ncbi.nlm.nih.gov/pubmed/36139648
http://dx.doi.org/10.3390/cancers14184488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9496734/
https://www.ncbi.nlm.nih.gov/pubmed/36139648
http://dx.doi.org/10.3390/cancers14184488

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